Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277153 | 0.75 | KDM4E (0.53) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL38650866 | 0.74 | AXL (0.38) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL8599120 | 0.72 | KDM4E (0.51) | ADORA2AADORA1MEN1KMT2AHTT | |
| SCHEMBL31025953 | 0.70 | AXL (0.42) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL377324 | 0.70 | KDM4E (0.56) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL28026979 | 0.68 | KDM4E (0.55) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL3577404 | 0.67 | AXL (0.48) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL21566251 | 0.67 | AXL (0.40) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL34461816 | 0.67 | AXL (0.40) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL2667285 | 0.67 | PDPK1 (0.42) | AXLMKNK1MKNK2PDPK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587473-B1 | Condensed pyridine derivatives as inhibitors of the effects of free radicals | SANOFI SA (FR) | 1998-11-11 | — | — | EP | disclosed |
| US-5468750-A | Antiinflammatory agents and autoimmune diseases | ELF SANOFI (FR) | 1995-11-21 | — | — | US | disclosed |
| US-5360799-A | Free radical inhibitors | ELF SANOFI (FR) | 1994-11-01 | — | — | US | disclosed |
| EP-0587473-A1 | Condensed pyridine derivatives as inhibitors of the effects of free radicals | SANOFI (FR) | 1994-03-16 | — | — | EP | disclosed |