Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553662 | 0.91 | KDM4C (0.38) | PDE4APDE4BPDE4CPDE4DADORA3 | |
| SCHEMBL8574177 | 0.91 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL1553974 | 0.89 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8572730 | 0.87 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL8571803 | 0.84 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8575517 | 0.84 | MLKL (0.40) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8570001 | 0.83 | HSD17B10 (0.36) | LMNAADORA3CNR2MEN1KMT2A | |
| SCHEMBL1552748 | 0.82 | PDE4D (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1552960 | 0.82 | PDE4D (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1552747 | 0.82 | PDE4D (0.61) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |