Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570515 | 1.00 | ESR2 (0.51) | ESR2DAPK3JAK2CSF1RRET | |
| SCHEMBL29746181 | 1.00 | ESR2 (0.51) | ESR2DAPK3JAK2CSF1RRET | |
| SCHEMBL8570510 | 1.00 | ESR2 (0.51) | ESR2DAPK3JAK2CSF1RRET | |
| SCHEMBL2361951 | 0.87 | CYP19A1 (0.51) | ESR2DAPK3JAK2CSF1RRET | |
| SCHEMBL2362933 | 0.86 | ESR2 (0.50) | ESR2MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL10536101 | 0.86 | ESR2 (0.50) | ESR2MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL26613583 | 0.83 | CYP11B2 (0.47) | ESR2MEN1KMT2AMAPTCYP2D6 | |
| SCHEMBL29746385 | 0.83 | CYP11B2 (0.47) | ESR2MEN1KMT2AMAPTCYP2D6 | |
| SCHEMBL17634083 | 0.82 | ESR2 (0.47) | ESR2MEN1KMT2AGAAMAPT | |
| SCHEMBL29746277 | 0.82 | ESR2 (0.50) | ESR2JAK2MTNR1AMTNR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |