Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574043 | 0.87 | ALDH1A1 (0.68) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL9805746 | 0.87 | CYP1A2 (0.83) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL3738802 | 0.86 | PDE4B (0.68) | ALDH1A1PDE4BHDAC1HDAC8MAPT | |
| SCHEMBL16672058 | 0.85 | ALDH1A1 (0.67) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL9365890 | 0.85 | ALDH1A1 (0.67) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL4083170 | 0.85 | ALDH1A1 (0.67) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL9805743 | 0.85 | CYP1A2 (0.81) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL9805821 | 0.85 | CYP1A2 (0.81) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL4020524 | 0.85 | ALDH1A1 (0.67) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL10415403 | 0.85 | ALDH1A1 (0.70) | CYP1A2HPGDALDH1A1CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841321-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-23 | — | — | US | disclosed |
| US-8841321-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-23 | — | — | US | disclosed |
| EP-1898914-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-15 | — | — | EP | disclosed |
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-02-25 | — | — | US | disclosed |
| WO-2007000435-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | NQO2, HRH1, HRH2 | CYP1A2 178/4885HPGD 754/4885ALDH1A1 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.