Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470323 | 0.90 | MAPT (0.52) | MAPTPOLBHSD17B10USP2KDM4E | |
| SCHEMBL8928795 | 0.86 | MAPT (0.52) | MAPTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL21775472 | 0.83 | MAPT (0.57) | MAPTPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL5068331 | 0.81 | MAPT (0.58) | MAPTPOLBNPSR1TDP1HSD17B10 | |
| SCHEMBL14698589 | 0.80 | MAPT (0.49) | MAPTPOLBL3MBTL1NPSR1TDP1 | |
| SCHEMBL15475992 | 0.80 | NPC1 (0.53) | MAPTPOLBL3MBTL1TDP1HSD17B10 | |
| SCHEMBL457202 | 0.80 | DPP4 (0.52) | MAPTPOLBNPSR1HSD17B10TSHR | |
| SCHEMBL15226771 | 0.79 | MAPT (0.48) | MAPTPOLBHSD17B10USP2KDM4E | |
| SCHEMBL15475806 | 0.78 | MAPT (0.56) | MAPTPOLBL3MBTL1NPSR1TDP1 | |
| SCHEMBL459359 | 0.77 | MAPT (0.52) | MAPTPOLBHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843951-A | Analgesic composition of pyrazolo(1,5-A) pyrimidines | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0795555-A1 | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1997-09-17 | — | — | EP | disclosed |