Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 13/20 | 0.63 |
| ▸ | HTR2B | P41595 | 13/20 | 0.63 |
| ▸ | HTR2A | P28223 | 9/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572506 | 0.91 | HTR2C (0.53) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8574781 | 0.90 | HTR2C (0.53) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8573974 | 0.89 | HTR2C (0.64) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8570870 | 0.88 | HTR2C (0.61) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8573905 | 0.88 | HTR2C (0.62) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8567723 | 0.88 | HTR2C (0.62) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8572332 | 0.87 | HTR2C (0.53) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8574314 | 0.87 | HTR2C (0.60) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8574255 | 0.85 | HTR2C (0.62) | HTR2CHTR2BHTR2AMEN1ALOX15 | |
| SCHEMBL8569901 | 0.85 | HTR2C (0.62) | HTR2CHTR2BHTR2AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |