Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.61 |
| ▸ | HTR2B | P41595 | 12/20 | 0.61 |
| ▸ | HTR2A | P28223 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573905 | 0.92 | HTR2C (0.62) | HTR2CHTR2BHTR2AALDH1A1MAPK1 | |
| SCHEMBL8567723 | 0.92 | HTR2C (0.62) | HTR2CHTR2BHTR2AALDH1A1ALOX15 | |
| SCHEMBL8572332 | 0.91 | HTR2C (0.53) | HTR2CHTR2BHTR2AALDH1A1MAPK1 | |
| SCHEMBL8574314 | 0.90 | HTR2C (0.60) | HTR2CHTR2BHTR2AALDH1A1MAPT | |
| SCHEMBL8573974 | 0.90 | HTR2C (0.64) | HTR2CHTR2BHTR2AALDH1A1MAPK1 | |
| SCHEMBL8574255 | 0.89 | HTR2C (0.62) | HTR2CHTR2BHTR2AALDH1A1MAPT | |
| SCHEMBL8569901 | 0.89 | HTR2C (0.62) | HTR2CHTR2BHTR2AALDH1A1MAPK1 | |
| SCHEMBL8811616 | 0.88 | HTR2C (0.63) | HTR2CHTR2BHTR2AALDH1A1MAPT | |
| SCHEMBL8570844 | 0.88 | HTR2C (0.63) | HTR2CHTR2BHTR2AALDH1A1MAPK1 | |
| SCHEMBL8571173 | 0.88 | POLB (0.51) | HTR2CHTR2BHTR2AALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |