Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.48 |
| ▸ | CDK9 | P50750 | 5/20 | 0.48 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 4/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28304021 | 0.83 | PDE10A (0.46) | DYRK1ADYRK1BCDK9DYRK2ALDH1A1 | |
| SCHEMBL8574385 | 0.81 | DHODH (0.49) | DYRK1ADYRK1BCDK9DYRK2ALDH1A1 | |
| SCHEMBL8574209 | 0.81 | DHODH (0.54) | ALDH1A1MAPTSMN1; SMN2DHODHPDE10A | |
| SCHEMBL8572609 | 0.79 | ALDH1A1 (0.43) | ALDH1A1MAPTSMN1; SMN2DHODHPDE10A | |
| SCHEMBL8569649 | 0.78 | CA12 (0.51) | DYRK1ACDK9ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8572735 | 0.78 | ALDH1A1 (0.42) | DYRK1ADYRK1BCDK9DYRK2ALDH1A1 | |
| SCHEMBL8574343 | 0.77 | CA12 (0.44) | DYRK1ADYRK1BCDK9DYRK2ALDH1A1 | |
| SCHEMBL8569460 | 0.77 | ALDH1A1 (0.40) | DYRK1ADYRK1BCDK9DYRK2ALDH1A1 | |
| SCHEMBL8572122 | 0.76 | ELANE (0.42) | ALDH1A1MAPTSMN1; SMN2DHODHPDE10A | |
| SCHEMBL6783762 | 0.75 | ALDH1A1 (0.59) | DYRK1AALDH1A1MAPTSMN1; SMN2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739133-A | N-ACYLATED AND ALKYLATED DERIVATIVES OF PYRIDAZINO(4,5-B)-QUINOLINES; EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS; STROKES; ANTIISCHEMIC AND HYPOGLYCEMIC AGENTS; PSYCHOSIS; NEUROGODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |
| US-5733910-A | Pyridazinedione compounds useful in the treating neurological disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-03-31 | — | — | US | disclosed |
| US-5604227-A | EXCITATORY AMINO ACID ANTAGONIST; MONO, DI OR TRI-ACETYLATION OR ALKYLATION | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1997-02-18 | — | — | US | disclosed |
| US-5599814-A | SUBSTITUTED PYRIDAZINO(4,5-B)QUINOLINES AS ANTAGONISTS OF EXCITATORY AMINO ACIDS | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1997-02-04 | — | — | US | disclosed |
| EP-0516297-B1 | Pyridazinediones and their use in the treatment of neurological disorders | ZENECA LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| EP-0516297-A1 | Pyridazinediones and their use in the treatment of neurological disorders | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |