Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | EDNRB | P24530 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818198 | 0.89 | TSHR (0.66) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7818802 | 0.86 | PDE10A (0.56) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8579808 | 0.83 | EDNRB (0.52) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8798932 | 0.83 | PDE10A (0.50) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8577253 | 0.82 | PDE10A (0.49) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL14361837 | 0.80 | MAPT (0.54) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8634323 | 0.78 | PADI4 (0.64) | ALDH1A1MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL9026946 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL8576064 | 0.75 | ALDH1A1 (0.62) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL27962915 | 0.75 | TDP1 (0.66) | TSHRALDH1A1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731321-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |