SCHEMBL8577434

SCHEMBL8577434

C=CCOC(=O)NCC=CO

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
MAPT P10636 2/20 0.37
CACNA1B Q00975 1/20 0.37
APBA1 Q02410 1/20 0.37
CYP3A4 P08684 1/20 0.35
CASP1 P29466 8/20 0.35
TSHR P16473 3/20 0.33
HSD17B10 Q99714 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPK1 P28482 1/20 0.33
ERN1 O75460 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
CSNK2A2 P19784 1/20 0.31
CSNK2A1 P68400 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3264928 0.86
SCHEMBL5497627 0.84 TSHR (0.45) MEN1KMT2AMAPTCACNA1BAPBA1
SCHEMBL31072722 0.81 MAPT (0.39) MEN1KMT2AMAPTCACNA1BAPBA1
SCHEMBL12443703 0.80 MEN1 (0.39) MEN1KMT2AMAPTCACNA1BAPBA1
SCHEMBL4632651 0.79 MEN1 (0.34) MEN1KMT2AMAPTCACNA1BAPBA1
SCHEMBL12393920 0.78 PTGS1 (0.37) MEN1KMT2AMAPTCACNA1BAPBA1
SCHEMBL13055388 0.77 MAPT (0.42) MEN1KMT2AMAPTCACNA1BAPBA1
SCHEMBL9486696 0.77 MAPT (0.42) MEN1KMT2AMAPTCACNA1BAPBA1
SCHEMBL2338040 0.76 GAA (0.39) KMT2ATSHRHSD17B10SMN1; SMN2ALDH1A1
SCHEMBL248893 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0537534-B1 Process for the preparation of N-(hydroxyalkyl)-carbamid acid alkyl esters BAYER AG (DE) 1994-06-22 EP claimed
US-5304650-A Reacting chloroformates with amino alcohol derivatives in aqueous alkali metal hydroxide solution BAYER AKTIENGESELLSCHAFT (DE) 1994-04-19 US claimed
JP-7258197-A None JP disclosed
US-5905165-A Alkyl N-(hydroxyalkyl) carbamates and their application in cosmetics, more particularly in hair compositions L'OREAL (FR) 1999-05-18 US disclosed
US-5849308-A Method of providing surfactant properties to a cosmetic or pharmaceutical composition using alkyl N-(hydroxyalkyl) carbamates L'OREAL (FR) 1998-12-15 US disclosed
US-5849308-A Method of providing surfactant properties to a cosmetic or pharmaceutical composition using alkyl N-(hydroxyalkyl) carbamates L'OREAL (FR) 1998-12-15 US disclosed
US-5788992-A COSMETICS AND HAIR CONDITIONERS L'OREAL (FR) 1998-08-04 US disclosed
US-5587169-A COMPRISING NONIONIC HYDROXYLATED GROUP; PROTECTIVE CREAM L'OREAL (FR) 1996-12-24 US disclosed
US-5587169-A COMPRISING NONIONIC HYDROXYLATED GROUP; PROTECTIVE CREAM L'OREAL (FR) 1996-12-24 US disclosed
JP-H07258197-A ALKYL N-(HYDROXYALKYL)CARBAMATE AND ITS APPLICATION IN COSMETICS L'OREAL SA 1995-10-09 JP disclosed
US-5304650-A Reacting chloroformates with amino alcohol derivatives in aqueous alkali metal hydroxide solution BAYER AKTIENGESELLSCHAFT (DE) 1994-04-19 US disclosed
US-5304650-A Reacting chloroformates with amino alcohol derivatives in aqueous alkali metal hydroxide solution BAYER AKTIENGESELLSCHAFT (DE) 1994-04-19 US disclosed
US-5304650-A Reacting chloroformates with amino alcohol derivatives in aqueous alkali metal hydroxide solution BAYER AKTIENGESELLSCHAFT (DE) 1994-04-19 US disclosed