Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11827252 | 0.87 | TP53 (0.58) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL11877575 | 0.86 | HTT (0.59) | HTTLMNAMAPTMEN1KMT2A | |
| SCHEMBL10334119 | 0.84 | CYP3A4 (0.56) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL19638004 | 0.84 | CYP3A4 (0.56) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL30977683 | 0.83 | TP53 (0.65) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL4455493 | 0.83 | TP53 (0.65) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL3959053 | 0.82 | HTT (1.00) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL21316522 | 0.81 | TP53 (0.58) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL19638028 | 0.80 | MAPT (0.64) | HTTLMNACYP3A4CYP2C19CNR2 | |
| SCHEMBL2883710 | 0.80 | MAPT (0.68) | HTTLMNATP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789419-A | CARDIOVASCULAR AND BRONCHIAL DISORDERS | SS PHARMACEUTICAL CO., LTD. (JP) | 1998-08-04 | — | — | US | disclosed |
| CN-1150420-A | 4-quinolinone derivative or salt thereof | SS PHARMACEUTICAL CO (JP) | 1997-05-21 | — | — | CN | disclosed |
| EP-0764639-A1 | 4-QUINOLINONE DERIVATIVE OR SALT THEREOF | SS PHARMACEUTICAL CO., LTD. (JP) | 1997-03-26 | — | — | EP | disclosed |