Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HEXA | P06865 | 1/20 | 0.46 |
| ▸ | HEXB | P07686 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495602 | 0.85 | PKM (0.58) | MAPTRAB9ATDP1L3MBTL1POLB | |
| SCHEMBL5153139 | 0.81 | MAPT (0.72) | MAPTRAB9ATDP1L3MBTL1KDM4E | |
| SCHEMBL1951546 | 0.79 | MAPT (1.00) | MAPTRAB9ATDP1L3MBTL1KDM4E | |
| SCHEMBL1064735 | 0.79 | CA1 (0.60) | MAPTRAB9AL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL2433046 | 0.79 | MAPT (0.77) | MAPTRAB9ATDP1L3MBTL1KDM4E | |
| SCHEMBL2469151 | 0.78 | MAPT (0.89) | MAPTRAB9ATDP1L3MBTL1KDM4E | |
| SCHEMBL27578576 | 0.77 | MAPT (0.74) | MAPTRAB9ATDP1L3MBTL1KDM4E | |
| SCHEMBL9339044 | 0.77 | MAPT (0.70) | MAPTRAB9ATDP1L3MBTL1KDM4E | |
| SCHEMBL5284759 | 0.77 | MAPT (1.00) | MAPTRAB9ATDP1L3MBTL1KDM4E | |
| SCHEMBL5054312 | 0.76 | MAPT (0.85) | MAPTRAB9ATDP1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929120-A | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |