Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 known ✓ | P00742 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 15/20 | 0.63 |
| ▸ | PLG | P00747 | 1/20 | 0.58 |
| ▸ | PLAT | P00750 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.58 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.58 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574446 | 0.91 | F2 (0.65) | F2F10PLGPLATPRSS1 | |
| Hydrochloric Acid SCHEMBL8576488 | 0.90 | F2 (0.66) | F2F10PLGPLATPRSS1 | |
| SCHEMBL7381434 | 0.85 | F2 (0.81) | F2 | |
| Hydrochloric Acid SCHEMBL8578705 | 0.84 | F2 (0.63) | F2F10PLGPLATPRSS1 | |
| Hydrochloric Acid SCHEMBL8576456 | 0.82 | F2 (0.62) | F2F10PLGPLATPRSS1 | |
| Hydrochloric Acid SCHEMBL8574574 | 0.80 | F2 (0.58) | F2F10PLGPLATPRSS1 | |
| SCHEMBL8578832 | 0.80 | F2 (0.48) | F2 | |
| SCHEMBL8580114 | 0.79 | F2 (0.56) | F2F10PLGPLATPRSS1 | |
| Acetic Acid SCHEMBL8581063 | 0.78 | F2 (0.50) | F2F10PLGPLATPRSS1 | |
| SCHEMBL7308912 | 0.78 | F2 (0.56) | F2F10PLGPLATPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763436-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |