SCHEMBL8580231

SCHEMBL8580231

CCCCc1nc(Cl)c(CO)n1Cc1ccc(S(=O)(=O)N(C)C2(C(=O)O)CCCCC2)cc1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 4/20 0.52
AGTR1 P30556 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8581340 0.91 AGTR2 (0.50) AGTR2AGTR1
SCHEMBL8581706 0.82 AGTR2 (0.45) AGTR2AGTR1
SCHEMBL8578765 0.82 AGTR2 (0.59) AGTR2AGTR1
SCHEMBL8581987 0.81 AGTR2 (0.58) AGTR2AGTR1
SCHEMBL8577738 0.80 AGTR2 (0.56) AGTR2AGTR1
SCHEMBL8582149 0.80 AGTR2 (0.56) AGTR2AGTR1
SCHEMBL8584164 0.78 AGTR2 (0.54) AGTR2AGTR1
SCHEMBL8579636 0.78 AGTR2 (0.54) AGTR2AGTR1
SCHEMBL8581826 0.78 AGTR2 (0.54) AGTR2AGTR1
SCHEMBL8583067 0.78 AGTR2 (0.54) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5741794-A PLATELET ACTIVATING FACTOR BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1998-04-21 US disclosed
EP-0620813-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF AND ANGIOTENSIN II BRITISH BIO-TECHNOLOGY LIMITED (GB) 1994-10-26 EP disclosed
WO-1993014069-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF AND ANGIOTENSIN II BRITISH BIO-TECHNOLOGY LIMITED (GB) 1993-07-22 WO disclosed