SCHEMBL858078

SCHEMBL858078

COC(=O)C(C)C(C)=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18867261 1.00
SCHEMBL16343058 0.97 SMN1; SMN2 (0.44)
SCHEMBL27485803 0.89 SMN1; SMN2 (0.42)
SCHEMBL275280 0.84 SMN1; SMN2 (0.52)
Dimethylformamide SCHEMBL2230176 0.84 TSHR (0.38)
SCHEMBL26658220 0.81 SMN1; SMN2 (0.50)
SCHEMBL10805452 0.81 SMN1; SMN2 (0.50)
Butyric Acid SCHEMBL27774826 0.81 FFAR3 (0.50)
SCHEMBL28808913 0.79 ALDH1A1 (0.37)
SCHEMBL1920162 0.79 SMN1; SMN2 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 266 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114213249-B Synthesis method of dolutegravir intermediate 瑞孚信江苏药业股份有限公司 2023-09-01 CN claimed
CN-116496296-A Dolutegravir derivative with anti-tumor function and preparation method thereof 河南师范大学 2023-07-28 CN claimed
CN-111978262-B Synthesis method of hydroxypyrimidine compound 西安近代化学研究所 2023-07-18 CN claimed
CN-111995522-B Synthetic method of pirimicarb intermediate 2-methyl acetoacetate 泰州百力化学股份有限公司 2022-03-29 CN claimed
CN-112753697-A Spraying aid for improving removal effect of harmful filamentous algae in farmland or water 北京广源益农化学有限责任公司 2021-05-07 CN claimed
CN-111995522-A Synthetic method of pirimicarb intermediate 2-methyl acetoacetate 泰州百力化学股份有限公司 2020-11-27 CN claimed
CN-106316843-A Synthesis method of 2-methyl methyl acetoacetate for pesticide production 陆开珍 2017-01-11 CN claimed
CN-104844598-A Synthesis method of 8-methoxy ethyl formate imidazole and [1,2a]pyridine-3-ethyl formate SHANDONG YOUBANG BIOCHEMICAL TECHNOLOGY CO LTD 2015-08-19 CN claimed
EP-0912467-B1 ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE RHODIA CHIMIE SA (FR) 2002-04-24 EP claimed
US-5091597-A Using zinc, cadmium, mercury or tin halide promoters SOCIETE NATIONALE ELF AQUITAINE (FR) 1992-02-25 US claimed
EP-4747249-A1 TREM2 MODULATORS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
CN-122010885-A Oraglycone intermediate, preparation method thereof and method for preparing key intermediate of Oraglycone 江西同和药业股份有限公司 2026-05-12 CN disclosed
US-20250287942-A1 FORMULATIONS FOR REPELLING BEES AND OTHER INSECTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-09-18 US disclosed
WO-2025017059-A1 TREM2 MODULATORS MUNA THERAPEUTICS APS (DK) 2025-01-23 WO disclosed
US-12032290-B2 Actinic ray-sensitive or radiation-sensitive resin composition, resist film, pattern forming method, and method for manufacturing electronic device FUJIFILM CORPORATION (JP) 2024-07-09 US disclosed
CN-87107938-A 3-pyrrolidyl sulfo--1-azabicyclo [3,2,0] hept-2-ene\"-2-formic acid cpds and preparation method thereof 1988-08-10 CN disclosed
US-4567004-A Process for the preparation of monomethyl-substituted methylene compounds BAYER AKTIENGESELLSCHAFT (DE) 1986-01-28 US disclosed
US-4536574-A REACTING SULFONYLOXYACETONITRILE WITH ALCOHOL, AMMONIUM CHLORIDE, ALKALI METAL THIOLATE AND KETOCARBOXYLIC ESTER BAYER AKTIENGESELLSCHAFT (DE) 1985-08-20 US disclosed
US-4515915-A Polyamide acid composition for preparing polyimide KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1985-05-07 US disclosed
EP-0114059-A2 Method of preparing a polyamide acid composition for preparing polyimide KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1984-07-25 EP disclosed