⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12361389 | 0.77 | — | — | |
| SCHEMBL605471 | 0.76 | — | — | |
| SCHEMBL10902117 | 0.75 | ALDH1A1 (0.35) | — | |
| SCHEMBL6178950 | 0.72 | — | — | |
| SCHEMBL618804 | 0.71 | — | — | |
| SCHEMBL56534 | 0.69 | — | — | |
| SCHEMBL114126 | 0.67 | — | — | |
| SCHEMBL1251550 | 0.67 | — | — | |
| SCHEMBL1987431 | 0.67 | — | — | |
| SCHEMBL10964652 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753671-A | Imidazopyridine derivatives as dual histamine (H1) and platelet activating factor (PAF) antagonists | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-05-19 | — | — | US | claimed |
| EP-0775139-A1 | IMIDAZOPYRIDINE DERIVATIVES AS DUAL HISTAMINE (H1) AND PLATELET ACTIVATING FACTOR (PAF) ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-05-28 | — | — | EP | claimed |
| WO-1996005201-A1 | IMIDAZOPYRIDINE DERIVATIVES AS DUAL HISTAMINE (H1) AND PLATELET ACTIVATING FACTOR (PAF) ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-02-22 | — | — | WO | claimed |
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-06-01 | — | — | US | disclosed |
| WO-2023072969-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023072961-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |
| EP-4173674-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-05-03 | — | — | EP | disclosed |
| EP-4173673-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-05-03 | — | — | EP | disclosed |
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | disclosed |
| US-5753671-A | Imidazopyridine derivatives as dual histamine (H1) and platelet activating factor (PAF) antagonists | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| EP-0775139-A1 | IMIDAZOPYRIDINE DERIVATIVES AS DUAL HISTAMINE (H1) AND PLATELET ACTIVATING FACTOR (PAF) ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005201-A1 | IMIDAZOPYRIDINE DERIVATIVES AS DUAL HISTAMINE (H1) AND PLATELET ACTIVATING FACTOR (PAF) ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |