Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eflornithine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ODC1 known ✓ | P11926 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | BLM | P54132 | 3/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | RAB9A | P51151 | 1/20 | 0.96 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.96 |
| ▸ | ARG1 | P05089 | 3/20 | 0.62 |
| ▸ | ARG2 | P78540 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eflornithine SCHEMBL26327 | 1.00 | ODC1 (1.00) | ODC1LMNABLMKDM4EMAPT | |
| D-Eflornithine SCHEMBL60699 | 1.00 | ODC1 (1.00) | ODC1LMNABLMKDM4EMAPT | |
| Eflornithine, (S)- SCHEMBL60698 | 1.00 | ODC1 (1.00) | ODC1LMNABLMKDM4EMAPT | |
| Eflornithine SCHEMBL6779168 | 0.98 | BLM (1.00) | ODC1LMNABLMKDM4EMAPT | |
| D-Eflornithine SCHEMBL7208883 | 0.98 | BLM (1.00) | ODC1LMNABLMKDM4EMAPT | |
| Eflornithine SCHEMBL3244711 | 0.98 | ODC1 (0.96) | ODC1LMNABLMKDM4EMAPT | |
| Eflornithine, (S)- SCHEMBL6779172 | 0.98 | BLM (1.00) | ODC1LMNABLMKDM4EMAPT | |
| Eflornithine SCHEMBL3022583 | 0.98 | BLM (1.00) | ODC1LMNABLMKDM4EMAPT | |
| D-Eflornithine SCHEMBL3244719 | 0.98 | ODC1 (0.96) | ODC1LMNABLMKDM4EMAPT | |
| Eflornithine, (S)- SCHEMBL1322403 | 0.98 | BLM (1.00) | ODC1LMNABLMKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025603-A1 | ISOMERIC PHARMACEUTICAL FORMULATION CONTAINING DFMO FOR THE TREATMENT OF CANCER | ILEX ONCOLOGY, INC. (US) | 1998-06-18 | — | — | WO | disclosed |