Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.59 |
| ▸ | CHUK | O15111 | 5/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | PAK4 | O96013 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
| ▸ | PRKACA | P17612 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 1/20 | 0.59 |
| ▸ | LTK | P29376 | 1/20 | 0.59 |
| ▸ | GRK5 | P34947 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858003 | 0.81 | IKBKB (0.64) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL30173273 | 0.80 | PRKCI (0.46) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL12127926 | 0.79 | IKBKB (0.70) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL7982849 | 0.77 | ABL1 (0.61) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL12127858 | 0.75 | IKBKB (0.93) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL4771643 | 0.75 | IKBKB (0.70) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL31065020 | 0.75 | IKBKB (0.70) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL4792517 | 0.75 | IKBKB (0.70) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL30674332 | 0.75 | IKBKB (0.70) | IKBKBCHUKAURKBDAPK3JAK2 | |
| SCHEMBL26930376 | 0.75 | IKBKB (0.70) | IKBKBCHUKAURKBDAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |