Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.36 |
| ▸ | IKBKB | O14920 | 3/20 | 0.35 |
| ▸ | CHUK | O15111 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28596900 | 0.82 | AXL (0.49) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL30173331 | 0.82 | AXL (0.49) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL28598985 | 0.80 | AXL (0.53) | PRKCIAXLJAK2JAK3RPS6KA3 | |
| SCHEMBL30173343 | 0.80 | AXL (0.53) | PRKCIAXLJAK2JAK3RPS6KA3 | |
| SCHEMBL30173309 | 0.80 | TTBK1 (0.51) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL30173307 | 0.80 | TTBK1 (0.51) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL28596880 | 0.80 | TTBK1 (0.51) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL858138 | 0.80 | IKBKB (0.59) | PRKCIJAK2JAK3RPS6KA3IKBKB | |
| SCHEMBL30173316 | 0.77 | AXL (0.61) | PRKCIAXLJAK2JAK3RPS6KA3 | |
| SCHEMBL28609163 | 0.77 | AXL (0.61) | PRKCIAXLJAK2JAK3RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113200983-B | Compound with pyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2023-01-03 | — | — | CN | disclosed |