Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29287791 | 0.84 | ELANE (0.42) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL1255890 | 0.83 | ELANE (0.47) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL544447 | 0.81 | MAOB (0.49) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL10946374 | 0.81 | ELANE (0.46) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL8587544 | 0.80 | ELANE (0.42) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL10187806 | 0.79 | ELANE (0.44) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL10973078 | 0.79 | ELANE (0.53) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL28089181 | 0.79 | ELANE (0.44) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL21235982 | 0.79 | ELANE (0.53) | ELANEMAOBALDH1A1ATML3MBTL1 | |
| SCHEMBL31257827 | 0.79 | ELANE (0.44) | ELANEMAOBALDH1A1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840614-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1996041638-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1996-12-27 | — | — | WO | disclosed |