Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 19/20 | 0.81 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20223085 | 0.90 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL2852499 | 0.88 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL20434278 | 0.87 | TLR8 (0.97) | TLR8TLR7 | |
| SCHEMBL6128041 | 0.85 | TLR8 (0.70) | TLR8TLR7 | |
| SCHEMBL15584199 | 0.79 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL8607557 | 0.76 | TLR8 (0.58) | TLR8TLR7 | |
| SCHEMBL20434273 | 0.74 | TLR8 (0.73) | TLR8TLR7 | |
| SCHEMBL6128301 | 0.72 | APP (0.57) | TLR8TLR7APP | |
| SCHEMBL20434274 | 0.71 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL20434302 | 0.71 | TLR8 (0.69) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662161-B2 | Pyrimidines and uses thereof | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-05-26 | — | — | US | disclosed |
| US-20180215720-A1 | PYRIMIDINES AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-08-02 | — | — | US | disclosed |
| US-20180215720-A1 | PYRIMIDINES AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-08-02 | — | — | US | disclosed |
| WO-1998020878-A1 | 5-[φ-(SUBSTITUTED ARYL)ALKENYLENE AND ALKYNYLENE]-2,4-DIAMINOPYRIMIDINES AS PESTICIDES | FMC CORPORATION (US) | 1998-05-22 | — | — | WO | disclosed |
| US-5696259-A | 2,4-diamino-5-iodopyrimidines useful as pesticide intermediates | FMC CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| US-5622954-A | INSECTICIDE | FMC CORPORATION (US) | 1997-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662161-B2 | Pyrimidines and uses thereof | TYMS, DPYD, TYMP | TLR8 1078/4885TLR7 445/4885APP 4372/4885 |
| US-20180215720-A1 | PYRIMIDINES AND USES THEREOF | TYMS, DPYD, TYMP | TLR8 1078/4885TLR7 445/4885APP 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.