Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 4/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29503829 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL30645689 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL29382791 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL29398487 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL1044856 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL7420121 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL1000115 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL29367120 | 0.89 | TLR2 (0.62) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL23447239 | 0.89 | TLR2 (0.59) | TLR2MDM2KMT2AMDM4TP53 | |
| SCHEMBL29561038 | 0.89 | TLR2 (0.51) | TLR2MDM2KMT2AMDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854410-A | Oligonucleoside cleavage compounds and therapies | GENTA INCORPORATED (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0542887-B1 | PSORALEN CONJUGATED METHYLPHOSPHONATE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS FOR CHRONIC MYELOGENOUS LEUKEMIA | GENTA INC (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0542928-A4 | IMPROVED NON-NUCLEOTIDE-BASED LINKER REAGENTS FOR OLIGOMERS | GENTA INC (US) | 1994-07-27 | — | — | EP | disclosed |
| EP-0542928-A1 | IMPROVED NON-NUCLEOTIDE-BASED LINKER REAGENTS FOR OLIGOMERS | GENTA INCORPORATED (US) | 1993-05-26 | — | — | EP | disclosed |
| EP-0542887-A1 | PSORALEN CONJUGATED METHYLPHOSPHONATE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS FOR CHRONIC MYELOGENOUS LEUKEMIA | GENTA INCORPORATED (US) | 1993-05-26 | — | — | EP | disclosed |
| WO-1992002641-A1 | PSORALEN CONJUGATED METHYLPHOSPHONATE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS FOR CHRONIC MYELOGENOUS LEUKEMIA | GENTA INCORPORATED (US) | 1992-02-20 | — | — | WO | disclosed |
| WO-1992002532-A1 | IMPROVED NON-NUCLEOTIDE-BASED LINKER REAGENTS FOR OLIGOMERS | GENTA INCORPORATED (US) | 1992-02-20 | — | — | WO | disclosed |