Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.88 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.88 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.88 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.88 |
| ▸ | PGR | P06401 | 2/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.88 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.88 |
| ▸ | SHBG | P04278 | 2/20 | 0.88 |
| ▸ | MAPT | P10636 | 2/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | AR | P10275 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone SCHEMBL2678895 | 0.97 | HIF1A (0.89) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL366439 | 0.97 | HIF1A (0.89) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL42272 | 0.97 | HIF1A (0.89) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL3098606 | 0.97 | HIF1A (0.89) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL250127 | 0.95 | HIF1A (0.93) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL3098612 | 0.95 | HIF1A (0.91) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL24900238 | 0.94 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL13046615 | 0.94 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL6370134 | 0.94 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 | |
| Hydrocortisone SCHEMBL10292969 | 0.94 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3618813-B1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | LUBRIZOL ADVANCED MAT INC (US) | 2022-07-06 | — | — | EP | claimed |
| US-20220016035-A1 | Extended Release Highly Loaded Drug Compositions | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2022-01-20 | — | — | US | claimed |
| US-20200113839-A1 | Extended Release Highly Loaded Drug Compositions | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2020-04-16 | — | — | US | claimed |
| EP-3618813-A1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | Lubrizol Advanced Materials, Inc. (US) | 2020-03-11 | — | — | EP | claimed |
| CN-110709068-A | Improved sustained release high load pharmaceutical compositions | 路博润先进材料公司 | 2020-01-17 | — | — | CN | claimed |
| WO-2018204317-A1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2018-11-08 | — | — | WO | claimed |
| EP-3618813-B1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | LUBRIZOL ADVANCED MAT INC (US) | 2022-07-06 | — | — | EP | disclosed |
| US-20220016035-A1 | Extended Release Highly Loaded Drug Compositions | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2022-01-20 | — | — | US | disclosed |
| US-20200113839-A1 | Extended Release Highly Loaded Drug Compositions | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| EP-3618813-A1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | Lubrizol Advanced Materials, Inc. (US) | 2020-03-11 | — | — | EP | disclosed |
| WO-2018204317-A1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2018-11-08 | — | — | WO | disclosed |
| CN-100421653-C | Method for inhibiting decrease in transdermal flux of drug by inhibiting closure of channel | ALZA CORP (US) | 2008-10-01 | — | — | CN | disclosed |
| CN-1473037-A | Method for inhibiting decrease in transdermal flux of drug by inhibiting closure of channel | — | 2004-02-04 | — | — | CN | disclosed |
| EP-0759750-A4 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 1998-05-27 | — | — | EP | disclosed |
| EP-0759750-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO, Howard, K. (US) | 1997-03-05 | — | — | EP | disclosed |
| WO-1995031194-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 1995-11-23 | — | — | WO | disclosed |