Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 2/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985013 | 0.87 | NPC1 (0.44) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL857416 | 0.87 | MAPK13 (0.45) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL858920 | 0.82 | MAPK13 (0.46) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL858294 | 0.82 | NPY5R (0.46) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL858140 | 0.81 | LATS1 (0.44) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL857451 | 0.81 | ADORA2A (0.48) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL858414 | 0.81 | IMPDH2 (0.50) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL858880 | 0.80 | CCNB2 (0.50) | CCNB2CDK1CCNB1CCNB3DYRK1A | |
| SCHEMBL858101 | 0.80 | MAPK14 (0.63) | LATS1LATS2MAPK13MAPK12MAPK11 | |
| SCHEMBL857640 | 0.80 | IMPDH2 (0.61) | LATS1LATS2MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |