Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755359 | 0.89 | HSD17B10 (0.51) | BRD4ALOX5APFEN1CTSKKDM4D | |
| SCHEMBL856038 | 0.89 | HSD17B10 (0.51) | BRD4ALOX5APFEN1CTSKKDM4D | |
| SCHEMBL3760824 | 0.89 | HSD17B10 (0.51) | BRD4ALOX5APFEN1CTSKKDM4D | |
| SCHEMBL3814254 | 0.87 | BRD4 (0.48) | BRD4ALOX5APFEN1CTSKJAK3 | |
| SCHEMBL3762883 | 0.85 | KDM4E (0.43) | KDM4EHSD17B10MMP2MMP13EPHX2 | |
| SCHEMBL6120288 | 0.85 | KDM4E (0.43) | KDM4EHSD17B10MMP2MMP13EPHX2 | |
| SCHEMBL3766037 | 0.83 | ALOX5AP (0.54) | BRD4ALOX5APFEN1JAK3JAK2 | |
| SCHEMBL17843470 | 0.83 | RORC (0.49) | BRD4ALOX5APFEN1CTSKKDM4D | |
| SCHEMBL3750670 | 0.83 | HSD17B10 (0.55) | BRD4ALOX5APFEN1NAMPTCKS1B | |
| SCHEMBL855425 | 0.81 | HSD17B10 (0.52) | BRD4ALOX5APFEN1RORCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |