Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.61 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.61 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | LTK | P29376 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.61 |
| ▸ | CDK8 | P49336 | 1/20 | 0.61 |
| ▸ | CDK7 | P50613 | 1/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.61 |
| ▸ | MST1R | Q04912 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588021 | 1.00 | NTRK1 (0.61) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8584743 | 0.87 | MAPK1 (0.46) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8583949 | 0.86 | NTRK1 (0.57) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8583955 | 0.86 | NTRK1 (0.57) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8584323 | 0.84 | NTRK1 (0.57) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8814373 | 0.84 | NTRK1 (0.57) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL7780481 | 0.82 | NTRK1 (0.83) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8811026 | 0.81 | NR4A2 (0.42) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8584740 | 0.81 | NR4A2 (0.42) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL7555701 | 0.80 | MAPK1 (0.65) | NTRK1NTRK3NTRK2PRKD3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |