Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8584740 | 1.00 | NR4A2 (0.42) | NR4A2BRD4LMNAMEN1KMT2A | |
| SCHEMBL8588021 | 0.81 | NTRK1 (0.61) | MAPK1NTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL8588017 | 0.81 | NTRK1 (0.61) | MAPK1NTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL8584743 | 0.80 | MAPK1 (0.46) | MEN1KMT2AMAPTRAB9AMAPK1 | |
| SCHEMBL5464903 | 0.78 | NTRK1 (0.59) | NR4A2LMNAMEN1KMT2AMITF | |
| SCHEMBL5481895 | 0.72 | TDP1 (0.52) | MEN1KMT2AMAPTRAB9ANTRK1 | |
| SCHEMBL8583949 | 0.68 | NTRK1 (0.57) | MAPK1NTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL8583955 | 0.68 | NTRK1 (0.57) | MAPK1NTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL8584323 | 0.66 | NTRK1 (0.57) | MAPK1NTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL8814373 | 0.66 | NTRK1 (0.57) | MAPK1NTRK1NTRK3NTRK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | claimed |