Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.42 |
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549370 | 0.96 | EDNRB (0.42) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8552698 | 0.94 | EDNRB (0.48) | EDNRBEDNRAPTPN1 | |
| SCHEMBL8546567 | 0.94 | EDNRB (0.40) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8548997 | 0.91 | EDNRB (0.43) | EDNRBEDNRA | |
| SCHEMBL8589486 | 0.89 | EDNRB (0.53) | EDNRBEDNRAPTPN1 | |
| SCHEMBL8547864 | 0.89 | EDNRB (0.49) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8551766 | 0.89 | EDNRB (0.43) | EDNRBEDNRA | |
| SCHEMBL8548410 | 0.87 | EDNRB (0.44) | EDNRBEDNRAMAPT | |
| SCHEMBL8547582 | 0.86 | EDNRB (0.52) | EDNRBEDNRAMAPT | |
| SCHEMBL8547985 | 0.86 | EDNRB (0.49) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |