Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.49 |
| ▸ | EDNRA | P25101 | 8/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548187 | 0.95 | EDNRB (0.46) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8548858 | 0.94 | EDNRB (0.45) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8552566 | 0.94 | EDNRB (0.53) | EDNRBEDNRAMAPTGRIN1GRIN2B | |
| SCHEMBL8547930 | 0.92 | EDNRB (0.47) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8549316 | 0.90 | EDNRB (0.52) | EDNRBEDNRAMAPT | |
| SCHEMBL8548697 | 0.90 | EDNRB (0.54) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8589488 | 0.89 | EDNRB (0.42) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8549139 | 0.89 | EDNRB (0.63) | EDNRBEDNRAPTPN1MAPT | |
| SCHEMBL8551476 | 0.88 | EDNRB (0.48) | EDNRBEDNRAMAPT | |
| SCHEMBL8547859 | 0.88 | EDNRB (0.44) | EDNRBEDNRAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |