SCHEMBL8593103

SCHEMBL8593103

O=C(O)CCc1cc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc(C(=O)c2ccc(F)cc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 2/20 0.67
TBXAS1 P24557 8/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8593383 0.90 TBXA2R (0.67) TBXA2RTBXAS1
SCHEMBL8595578 0.87 TBXAS1 (0.77) TBXA2RTBXAS1
SCHEMBL8593101 0.87 TBXA2R (0.64) TBXA2RTBXAS1
SCHEMBL8592974 0.87 TBXA2R (0.64) TBXA2RTBXAS1
SCHEMBL8593398 0.86 TBXAS1 (0.52) TBXA2RTBXAS1
SCHEMBL8592982 0.84 TBXAS1 (0.70) TBXA2RTBXAS1
SCHEMBL8594726 0.84 TBXA2R (0.65) TBXA2RTBXAS1
SCHEMBL8593839 0.83 TBXAS1 (0.71) TBXA2RTBXAS1
SCHEMBL14327858 0.81 TBXA2R (1.00) TBXA2RTBXAS1
SCHEMBL9130164 0.81 TBXA2R (0.81) TBXA2RTBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1037176-C Benzenealkanoic acids for cardiovascular diseases PFIZER RES & DEV (IE) 1998-01-28 CN disclosed
EP-0662950-B1 BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES PFIZER LTD (GB) 1998-01-14 EP disclosed
US-5618941-A Benzenealkanoic acids for cardiovascular diseases PFIZER INC. (US) 1997-04-08 US disclosed
EP-0662950-A1 BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES Pfizer Limited (GB) 1995-07-19 EP disclosed
WO-1994006761-A1 BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES PFIZER LIMITED (GB) 1994-03-31 WO disclosed