SCHEMBL8593171

SCHEMBL8593171

CCOC(=O)N1C(=O)C(O[Si](C(C)C)(C(C)C)C(C)C)C1c1ccsc1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 13/20 0.45
ALDH1A1 P00352 5/20 0.42
HSD17B10 Q99714 3/20 0.42
KDM4E B2RXH2 3/20 0.42
POLB P06746 2/20 0.42
HPGD P15428 2/20 0.42
GAA P10253 1/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
MCL1 Q07820 1/20 0.40
SIRT3 Q9NTG7 1/20 0.38
SIRT5 Q9NXA8 1/20 0.38
MAPT P10636 1/20 0.37
TSHR P16473 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
P2RX3 P56373 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8396915 1.00 ADORA2B (0.45) ADORA2BALDH1A1HSD17B10KDM4EPOLB
SCHEMBL8393365 0.88 ADORA2B (0.35) ADORA2BALDH1A1HSD17B10KDM4EPOLB
SCHEMBL8393391 0.85 ADORA2B (0.35) ADORA2BALDH1A1HSD17B10KDM4EPOLB
SCHEMBL7776769 0.85 ELANE (0.47) ALDH1A1KDM4EPOLBHPGDGAA
SCHEMBL8393390 0.85 ELANE (0.36) ALDH1A1KDM4EMAPTSMN1; SMN2
SCHEMBL8393337 0.84 KDM4E (0.40) ALDH1A1HSD17B10KDM4EGAAMAPT
SCHEMBL8595029 0.84 KDM4E (0.40) ALDH1A1HSD17B10KDM4EGAAMAPT
SCHEMBL8392850 0.84 ELANE (0.38) ALDH1A1KDM4EPOLBGAAMAPT
SCHEMBL8596463 0.84 ELANE (0.38) ALDH1A1KDM4EPOLBGAAMAPT
SCHEMBL8593871 0.83 NPSR1 (0.43) ALDH1A1HPGDMAPTTSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0817769-A1 NOVEL BORNEOL ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE SCHERING AKTIENGESELLSCHAFT (DE) 1998-01-14 EP disclosed