Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859223 | 0.83 | PDK1 (0.31) | PDK1PARP1TNKS2PARP2 | |
| SCHEMBL856255 | 0.80 | PDK1 (0.33) | PDK1 | |
| SCHEMBL856254 | 0.78 | PDK1 (0.32) | PDK1 | |
| SCHEMBL855662 | 0.78 | PDK1 (0.36) | PDK1PARP1TNKS2PARP2 | |
| SCHEMBL856797 | 0.77 | PDK1 (0.31) | PDK1 | |
| SCHEMBL854443 | 0.77 | PDK1 (0.31) | PDK1 | |
| SCHEMBL6128119 | 0.75 | PDK1 (0.31) | PDK1PARP1TNKS2PARP2 | |
| SCHEMBL856523 | 0.75 | PDK1 (0.31) | PDK1 | |
| SCHEMBL856470 | 0.74 | KMT2A (0.41) | PDK1 | |
| SCHEMBL857386 | 0.74 | PDK1 (0.33) | PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |