Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | POLB | P06746 | 6/20 | 0.64 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | MAP3K5 | Q99683 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8595238 | 1.00 | MEN1 (0.64) | MEN1KMT2APOLBDNMT1BLM | |
| SCHEMBL3892037 | 0.79 | MAP3K5 (0.79) | MEN1KMT2APOLBDNMT1BLM | |
| SCHEMBL3892035 | 0.79 | MAP3K5 (0.79) | MEN1KMT2APOLBDNMT1BLM | |
| SCHEMBL3969218 | 0.78 | MEN1 (0.69) | MEN1KMT2APOLBBLMMAPT | |
| SCHEMBL3969214 | 0.78 | MEN1 (0.69) | MEN1KMT2APOLBBLMMAPT | |
| SCHEMBL13056331 | 0.78 | MAP3K5 (0.78) | MAP3K5MAPTAPEX1STAT3 | |
| SCHEMBL8594085 | 0.78 | MAP3K5 (0.78) | MAP3K5MAPTAPEX1STAT3 | |
| SCHEMBL8594082 | 0.78 | MAP3K5 (0.78) | MAP3K5MAPTAPEX1STAT3 | |
| SCHEMBL6790996 | 0.77 | PTPN12 (0.76) | MEN1KMT2APOLBDNMT1BLM | |
| SCHEMBL13220182 | 0.77 | MAPT (0.67) | MEN1KMT2APOLBDNMT1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998053790-A2 | COMPOUNDS THAT INHIBIT THE BINDING OF VASCULAR ENDOTHELIAL GROWTH FACTOR TO ITS RECEPTORS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-12-03 | — | — | WO | claimed |