SCHEMBL8596143

SCHEMBL8596143

Cc1ccccc1-c1nc2c([nH]1)c(=O)n(C)c(=O)n2C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.76
ALDH1A1 P00352 2/20 0.76
HPGD P15428 2/20 0.76
TDP1 Q9NUW8 1/20 0.76
ADORA2B P29275 2/20 0.70
HSD17B10 Q99714 2/20 0.70
CYP1A2 P05177 1/20 0.70
ADORA3 P0DMS8 1/20 0.70
ADORA2A P29274 1/20 0.70
ADORA1 P30542 1/20 0.70
BLM P54132 1/20 0.70
NPSR1 Q6W5P4 1/20 0.70
USP2 O75604 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8595301 0.86 KDM4E (0.72) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL25090354 0.86 KDM4E (0.72) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL2119734 0.86 KDM4E (0.72) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL10614178 0.86 KDM4E (1.00) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL29429838 0.85 KDM4E (0.70) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL516349 0.85 KDM4E (0.70) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL8598385 0.84 KDM4E (0.69) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL25090658 0.84 PDE5A (0.72) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL10712628 0.84 KDM4E (0.76) KDM4EALDH1A1HPGDTDP1ADORA2B
SCHEMBL25090430 0.83 KDM4E (0.67) KDM4EALDH1A1HPGDTDP1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0817618-A1 SOFT GELATIN CAPSULE WITH A GELATIN SHELL COMPRISING XANTHINE DERIVATIVE THE PROCTER & GAMBLE COMPANY (US) 1998-01-14 EP disclosed
US-5641512-A SHELL CONTAINS XANTHINE DERIVATIVE THE PROCTER & GAMBLE COMPANY (US) 1997-06-24 US disclosed
WO-1996029997-A1 SOFT GELATIN CAPSULE WITH A GELATIN SHELL COMPRISING XANTHINE DERIVATIVE THE PROCTER & GAMBLE COMPANY (US) 1996-10-03 WO disclosed
EP-0165308-B1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME Richardson-Vicks, Inc. (US) 1989-03-22 EP disclosed
EP-0167566-A4 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME. SUNSHINE ABRAHAM (US) 1987-06-29 EP disclosed
EP-0165308-A4 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME. RICHARDSON VICKS INC (US) 1986-05-16 EP disclosed
US-4567183-A SYNERGISTIC, POTENTIATION ANALGESIC ASSOCIATES (US) 1986-01-28 US disclosed
EP-0167566-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME SUNSHINE, Abraham (US) 1986-01-15 EP disclosed
EP-0165308-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME. RICHARDSON VICKS INC (US) 1985-12-27 EP disclosed
US-4558051-A Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same RICHARDSON-VICKS, INC. (US) 1985-12-10 US disclosed
WO-1985002542-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME SUNSHINE ABRAHAM 1985-06-20 WO disclosed
WO-1985002540-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME RICHARDSON-VICKS, INC. (US) 1985-06-20 WO disclosed