Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221242 | 0.78 | KMT2A (0.76) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL29391624 | 0.78 | KMT2A (0.76) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL31690832 | 0.76 | MEN1 (0.55) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL6574416 | 0.75 | KMT2A (0.73) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| Bromide SCHEMBL28368455 | 0.75 | KMT2A (0.73) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL6175584 | 0.75 | KMT2A (0.73) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL4243882 | 0.75 | KMT2A (0.73) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL11133606 | 0.75 | KMT2A (0.73) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL30947359 | 0.75 | KMT2A (0.73) | ADRA2AADRA2CMEN1KMT2ANPC1 | |
| SCHEMBL6175579 | 0.75 | KMT2A (0.73) | ADRA2AADRA2CMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220372136-A1 | METHODS FOR TREATING ANEMIA OF CHRONIC DISEASE | DISC MEDICINE, INC. (US) | 2022-11-24 | — | — | US | disclosed |
| US-20220372135-A1 | METHODS FOR TREATING MYELOFIBROSIS AND RELATED CONDITIONS | DISC MEDICINE, INC. (US) | 2022-11-24 | — | — | US | disclosed |
| EP-4041243-A1 | METHODS FOR TREATING ANEMIA OF CHRONIC DISEASE | Disc Medicine, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| EP-4041241-A1 | METHODS FOR TREATING MYELOFIBROSIS AND RELATED CONDITIONS | Disc Medicine, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114761013-A | Methods of treating myelofibrosis and related disorders | 迪斯克医药公司 | 2022-07-15 | — | — | CN | disclosed |
| WO-1998024776-A1 | PREPARATION OF AN AMINOARYLAMINOARAZOLE | THE DOW CHEMICAL COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |
| US-5739344-A | Preparation of an aminoarylaminoarazole | THE DOW CHEMICAL COMPANY (US) | 1998-04-14 | — | — | US | disclosed |