Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.40 |
| ▸ | HTR3B | O95264 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860464 | 0.84 | HRH4 (0.58) | HRH4HRH3CYP1A2HSD17B10HTR3E | |
| SCHEMBL859614 | 0.81 | HRH4 (0.59) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL16775715 | 0.78 | HRH3 (0.59) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL30834235 | 0.78 | HRH3 (0.59) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL859712 | 0.78 | HRH4 (0.60) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL860012 | 0.77 | HRH3 (0.51) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL1588650 | 0.74 | HRH4 (1.00) | HRH4HRH3HTR2CHTR7HTR6 | |
| SCHEMBL6976678 | 0.72 | HRH3 (0.65) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL11919248 | 0.72 | HRH3 (0.59) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL859700 | 0.71 | HRH4 (0.72) | HRH4HRH3CYP1A2HSD17B10PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524363-A | — | — | 2011-09-01 | — | — | JP | claimed |
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | claimed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | claimed |