Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859671 | 0.84 | HRH4 (0.59) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL14004731 | 0.77 | HRH4 (0.61) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL1587961 | 0.73 | HRH4 (1.00) | HRH4HRH3HTR6ADRA2BADRA2C | |
| SCHEMBL14029975 | 0.72 | HRH4 (0.67) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL1588697 | 0.71 | HRH4 (1.00) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL2166051 | 0.70 | HRH4 (1.00) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL2190955 | 0.70 | HRH4 (0.65) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL29997962 | 0.70 | HRH4 (0.65) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL19233404 | 0.70 | HRH4 (0.81) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL8475763 | 0.69 | HRH4 (0.63) | HRH4HRH3ALDH1A1CYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524363-A | — | — | 2011-09-01 | — | — | JP | claimed |
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | claimed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | claimed |
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | disclosed |