Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 5/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | METAP1 | P53582 | 6/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874116 | 1.00 | DRD3 (0.46) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8598585 | 1.00 | DRD3 (0.46) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8873173 | 0.89 | ACHE (0.55) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8596659 | 0.89 | ACHE (0.55) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8596660 | 0.89 | ACHE (0.55) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8599815 | 0.84 | DRD3 (0.49) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8873012 | 0.84 | DRD3 (0.49) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8595401 | 0.83 | METAP1 (0.60) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8873827 | 0.83 | METAP1 (0.60) | DRD3DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL8595405 | 0.83 | METAP1 (0.60) | DRD3DRD2HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |