Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | PARP1 | P09874 | 10/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19268312 | 0.88 | PARP1 (0.53) | KDM4EHPGDPARP1PRKD3MAP4K4 | |
| SCHEMBL6170661 | 0.82 | PARP1 (0.64) | KDM4EPARP1MEN1KMT2APOLB | |
| SCHEMBL28790557 | 0.80 | PARP1 (0.54) | KDM4EPARP1MEN1KMT2APOLB | |
| SCHEMBL7480886 | 0.80 | PARP1 (0.54) | KDM4EHPGDPARP1MEN1GAA | |
| SCHEMBL11830014 | 0.80 | PARP1 (0.57) | KDM4EPARP1MEN1KMT2AMAPT | |
| SCHEMBL2369650 | 0.80 | KDM4E (0.65) | KDM4EHPGDPARP1MEN1GAA | |
| SCHEMBL8597971 | 0.79 | KDM4E (1.00) | KDM4EHPGDPARP1MEN1GAA | |
| SCHEMBL2369095 | 0.78 | PARP1 (1.00) | KDM4EHPGDPARP1MEN1GAA | |
| SCHEMBL7485575 | 0.78 | CHEK1 (0.52) | KDM4EPARP1MAPTALDH1A1HSD17B10 | |
| SCHEMBL7475443 | 0.78 | PARP1 (0.55) | KDM4EHPGDPARP1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |