SCHEMBL7475443

SCHEMBL7475443

CCOC(=O)c1cccc2[nH]c(SC)nc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.55
PRKD3 O94806 1/20 0.50
MAP4K4 O95819 1/20 0.50
PIM1 P11309 1/20 0.50
CLK2 P49760 1/20 0.50
MAP4K2 Q12851 1/20 0.50
CAMK2D Q13557 1/20 0.50
DYRK1A Q13627 1/20 0.50
PIM3 Q86V86 1/20 0.50
AURKB Q96GD4 1/20 0.50
PRKD2 Q9BZL6 1/20 0.50
CLK4 Q9HAZ1 1/20 0.50
STK17A Q9UEE5 1/20 0.50
MAP4K5 Q9Y4K4 1/20 0.50
LMNA P02545 3/20 0.47
TSHR P16473 2/20 0.47
RIPK1 Q13546 1/20 0.46
PKN1 Q16512 1/20 0.46
PKN2 Q16513 1/20 0.46
ALDH1A1 P00352 5/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15808958 0.85 PKN1 (0.62) PARP1LMNARIPK1PKN1PKN2
SCHEMBL6170661 0.83 PARP1 (0.64) PARP1PRKD3MAP4K4PIM1CLK2
SCHEMBL19268312 0.82 PARP1 (0.53) PARP1PRKD3MAP4K4PIM1CLK2
SCHEMBL11830014 0.81 PARP1 (0.57) PARP1PRKD3MAP4K4PIM1CLK2
SCHEMBL7480886 0.81 PARP1 (0.54) PARP1PRKD3MAP4K4PIM1CLK2
SCHEMBL28790557 0.81 PARP1 (0.54) PARP1PRKD3MAP4K4PIM1CLK2
SCHEMBL6948231 0.81 PARP1 (0.69) PARP1PRKD3MAP4K4PIM1CLK2
SCHEMBL7969798 0.80 DHODH (0.58) PARP1ALDH1A1TDP1KDM4EHPGD
SCHEMBL6842031 0.79 PARP1 (0.66) PARP1PRKD3MAP4K4PIM1CLK2
SCHEMBL7485575 0.79 CHEK1 (0.52) PARP1PRKD3MAP4K4PIM1CLK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed
EP-0946519-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 EP disclosed
WO-1998024771-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-11 WO disclosed