Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTGIR | P43119 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8599348 | 0.64 | MEN1 (0.35) | LMNATHRBHPGDL3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL8597511 | 0.64 | MEN1 (0.33) | LMNATHRBHPGDL3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL9251092 | 0.64 | KMT2A (0.36) | LMNATHRBHPGDL3MBTL1MEN1 | |
| SCHEMBL12914594 | 0.64 | NPSR1 (0.61) | LMNATHRBHPGDL3MBTL1MEN1 | |
| SCHEMBL9004614 | 0.62 | MAPT (0.59) | LMNATHRBL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8597073 | 0.62 | MEN1 (0.35) | LMNATHRBHPGDL3MBTL1MEN1 | |
| SCHEMBL29941486 | 0.61 | NPSR1 (0.47) | LMNAL3MBTL1MEN1KMT2ANPSR1 | |
| SCHEMBL264029 | 0.61 | NPSR1 (0.56) | LMNATHRBHPGDL3MBTL1MEN1 | |
| SCHEMBL900147 | 0.61 | NPSR1 (0.56) | HPGDL3MBTL1MEN1KMT2ANPSR1 | |
| SCHEMBL1563099 | 0.59 | NPSR1 (0.58) | HPGDL3MBTL1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726314-A | ACETYLCHOLINESTERASE INHIBITORS AS NERVE AGENT ANTIDOTES | GEORGIA TECH RESEARCH CORP. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5714615-A | ACETYLCHOLINESTERASE ENZYME INHIBITOR, STIMULATE NICOTINIC RECEPTORS IN CENTRAL NERVOUS SYSTEM | GEORGIA TECH RESEARCH CORPORATION (US) | 1998-02-03 | — | — | US | disclosed |