SCHEMBL8600161

SCHEMBL8600161

O=C1NC(Cc2ccccc2)CN1C1C=CCCN1

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.38
SCD O00767 1/20 0.34
PLG P00747 2/20 0.34
HDAC8 Q9BY41 2/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA4 P22748 2/20 0.33
CA9 Q16790 2/20 0.33
OTUD7B Q6GQQ9 1/20 0.33
GRM2 Q14416 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3249080 0.73 GBA1 (0.49) POLBSCDGRM2SLC6A2SLC6A4
SCHEMBL8602568 0.72 KMT2A (0.45) POLB
SCHEMBL22560041 0.68 POLB (0.41) POLBSCDHDAC8OTUD7BGRM2
SCHEMBL5505488 0.68 POLB (0.43) POLBHDAC8
SCHEMBL3248256 0.68 CHRM3 (0.54)
SCHEMBL13986105 0.67 HPGD (0.46) POLBHDAC8
SCHEMBL1291380 0.65 SCD (0.41) POLBSCDOTUD7BGRM2
SCHEMBL29721617 0.64 SCD (0.42) POLBSCDCA1CA2CA4
SCHEMBL4679652 0.63 POLB (0.58) POLBPLG
SCHEMBL3068478 0.62 POLB (0.53) POLBPLGHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5789425-A Imidazolidinone derivatives, their acid adducts and therapeutic drugs for senile dementia KYORIN PHARMACEUTICAL CO., LTD. (JP) 1998-08-04 US disclosed