SCHEMBL8600465

SCHEMBL8600465

COc1ccc2c(C(=O)c3ccc(OCCCl)cc3)c(-c3ccccc3)sc2c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 17/20 0.62
ESR2 Q92731 17/20 0.62
CNR1 P21554 1/20 0.60
CNR2 P34972 1/20 0.60
TUBB4A P04350 1/20 0.54
TUBB P07437 1/20 0.54
TUBA3C P0DPH7 1/20 0.54
TUBA1B P68363 1/20 0.54
TUBA4A P68366 1/20 0.54
TUBB4B P68371 1/20 0.54
TUBB3 Q13509 1/20 0.54
TUBB2A Q13885 1/20 0.54
TUBB8 Q3ZCM7 1/20 0.54
TUBA3E Q6PEY2 1/20 0.54
TUBA1A Q71U36 1/20 0.54
TUBA1C Q9BQE3 1/20 0.54
TUBB6 Q9BUF5 1/20 0.54
TUBB2B Q9BVA1 1/20 0.54
TUBB1 Q9H4B7 1/20 0.54
ENPP3 O14638 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26625437 0.91 ESR1 (0.64) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL30619842 0.91 ESR1 (0.64) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL11547336 0.88 ESR1 (0.61) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL11547494 0.88 CNR2 (0.76) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL8596134 0.88 ESR1 (0.60) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL11547042 0.86 CNR1 (0.70) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL8597235 0.86 ESR1 (0.58) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL8600742 0.85 CNR1 (0.57) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL8599094 0.85 ESR1 (0.58) ESR1ESR2CNR1CNR2TUBB4A
SCHEMBL7970907 0.84 ESR1 (0.73) ESR1ESR2CNR1CNR2TUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641791-B1 NOVEL BENZOTHIOPHENE DERIVATIVE TEIKOKU HORMONE MFG CO LTD (JP) 1998-01-28 EP disclosed
US-5556876-A ANTICHOLESTEROL AGENTS USING DERIVATIVES OF BENZOTHIENYL KETONES ELI LILLY AND COMPANY (US) 1996-09-17 US disclosed
US-5552433-A ADMINISTERING SPECIFIED COMPOUND TO A HUMAN ELI LILLY AND COMPANY (US) 1996-09-03 US disclosed
US-5521172-A BENZOTHIOPHENE KETONES WITH BENZENE DERIVATIVES ELI LILLY AND COMPANY (US) 1996-05-28 US disclosed
US-5482950-A BENZOTHIOPHENE DERIVATIVE ELI LILLY AND COMPANY (US) 1996-01-09 US disclosed
US-5480904-A BENZOTHIOPHENE COMPOUND ELI LILLY AND COMPANY (US) 1996-01-02 US disclosed
US-5472962-A Antiestrogenic agents TEIKOKU HORMONE MFG. CO., LTD. (JP) 1995-12-05 US disclosed
US-5441964-A Especially post-memopausal women ELI LILLY AND COMPANY (US) 1995-08-15 US disclosed
EP-0657162-A1 Methods for lowering serum cholesterol ELI LILLY AND COMPANY (US) 1995-06-14 EP disclosed
EP-0651998-A1 Methods for inhibiting bone loss ELI LILLY AND COMPANY (US) 1995-05-10 EP disclosed
EP-0650724-A1 Methods for inhibiting uterine fibrosis ELI LILLY AND COMPANY (US) 1995-05-03 EP disclosed
EP-0641791-A1 NOVEL BENZOTHIOPHENE DERIVATIVE TEIKOKU HORMONE MFG. CO., LTD. (JP) 1995-03-08 EP disclosed