Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TK2 | O00142 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026652 | 0.84 | TK1 (0.43) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL5982761 | 0.84 | TK1 (0.43) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL7148864 | 0.81 | TK1 (0.41) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL7148871 | 0.81 | TK1 (0.41) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL9708965 | 0.78 | TK1 (0.40) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL28478745 | 0.78 | TK1 (0.37) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL5613016 | 0.77 | TK1 (0.43) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL5730127 | 0.77 | TK1 (0.41) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL5964929 | 0.77 | TK1 (0.41) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL11678022 | 0.77 | TK1 (0.44) | TK1LMNASMN1; SMN2TK2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708161-A | Nucleoside phosphorothioate derivatives, synthesis and use thereof | KING'S COLLEGE LONDON (GB) | 1998-01-13 | — | — | US | disclosed |
| EP-0577725-A4 | TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES | UNIV FLORIDA (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0577725-A1 | TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES | UNIVERSITY OF FLORIDA (US) | 1994-01-12 | — | — | EP | disclosed |
| WO-1992017185-A1 | TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES | UNIVERSITY OF FLORIDA (US) | 1992-10-15 | — | — | WO | disclosed |