SCHEMBL860055

SCHEMBL860055

N#CCC(C1CCN(c2nc3cccnc3o2)C1)n1cc(-c2ncnc3[nH]ccc23)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AXL P30530 2/20 1.00
MERTK Q12866 1/20 1.00
TYRO3 Q06418 2/20 0.67
JAK2 O60674 13/20 0.66
JAK1 P23458 13/20 0.66
JAK3 P52333 3/20 0.63
DAPK3 O43293 2/20 0.63
PAK4 O96013 2/20 0.63
ABL1 P00519 2/20 0.63
RET P07949 2/20 0.63
LTK P29376 2/20 0.63
CSNK1A1 P48729 2/20 0.63
CLK2 P49760 2/20 0.63
TNK2 Q07912 2/20 0.63
ROCK1 Q13464 2/20 0.63
DYRK1A Q13627 2/20 0.63
IKBKE Q14164 2/20 0.63
NTRK3 Q16288 2/20 0.63
NTRK2 Q16620 2/20 0.63
LRRK2 Q5S007 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16517664 1.00 AXL (1.00) AXLMERTKTYRO3JAK2JAK1
SCHEMBL16517815 1.00 AXL (1.00) AXLMERTKTYRO3JAK2JAK1
SCHEMBL30819101 1.00 AXL (1.00) AXLMERTKTYRO3JAK2JAK1
SCHEMBL29380316 1.00 AXL (1.00) AXLMERTKTYRO3JAK2JAK1
SCHEMBL13058317 0.92 AXL (0.85) AXLMERTKTYRO3JAK2JAK1
SCHEMBL860616 0.92 AXL (0.85) AXLMERTKTYRO3JAK2JAK1
SCHEMBL13058327 0.92 AXL (0.85) AXLMERTKTYRO3JAK2JAK1
SCHEMBL860426 0.92 AXL (0.85) AXLMERTKTYRO3JAK2JAK1
SCHEMBL859509 0.90 AXL (0.82) AXLMERTKTYRO3JAK2JAK1
SCHEMBL17732355 0.90 AXL (0.81) AXLMERTKTYRO3JAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 278 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4501409-A2 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR Incyte Holdings Corporation (US) 2025-02-05 EP claimed
EP-3773593-B1 TREATMENT OF HIDRADENITIS SUPPURATIVA USING JAK INHIBITORS INCYTE CORP (US) 2024-05-15 EP claimed
US-20240091234-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS INCYTE CORPORATION 2024-03-21 US claimed
US-20240058343-A1 TREATMENT OF URTICARIA USING JAK INHIBITORS INCYTE CORPORATION 2024-02-22 US claimed
EP-4274578-A1 COMBINATION THERAPY COMPRISING JAK PATHWAY INHIBITOR AND ROCK INHIBITOR Incyte Corporation (US) 2023-11-15 EP claimed
US-20220378791-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES INCYTE CORPORATION 2022-12-01 US claimed
US-20220226327-A1 COMBINATION THERAPY COMPRISING JAK PATHWAY INHIBITOR AND ROCK INHIBITOR INCYTE CORPORATION 2022-07-21 US claimed
WO-2022150676-A1 COMBINATION THERAPY COMPRISING JAK PATHWAY INHIBITOR AND ROCK INHIBITOR INCYTE CORPORATION (US) 2022-07-14 WO claimed
US-11324749-B2 Combination therapy for treatment of hematological diseases INCYTE CORPORATION (US) 2022-05-10 US claimed
EP-3873433-A1 COMBINATION THERAPY FOR TREATMENT OF HEMATOLOGICAL DISEASES Incyte Corporation (US) 2021-09-08 EP claimed
US-20190111058-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES INCYTE CORPORATION 2019-04-18 US claimed
US-9498467-B2 Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 INCYTE CORPORATION (US) 2016-11-22 US claimed
US-9334274-B2 N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors INCYTE HOLDINGS CORPORATION (US) 2016-05-10 US claimed
US-20160000795-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS INCYTE CORPORATION (US) 2016-01-07 US claimed
US-20150342952-A1 TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 INCYTE CORPORATION (US) 2015-12-03 US claimed
US-20150246046-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES INCYTE CORPORATION 2015-09-03 US claimed
US-20150065447-A1 SURVIVAL BENEFIT IN PATIENTS WITH SOLID TUMORS WITH ELEVATED C-REACTIVE PROTEIN LEVELS INCYTE CORPORATION (US) 2015-03-05 US claimed
US-20140221379-A1 N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS INCYTE CORPORATION (US) 2014-08-07 US claimed
US-8716303-B2 N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors INCYTE CORPORATION (US) 2014-05-06 US claimed
US-20100298334-A1 N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS INCYTE CORPORATION 2010-11-25 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160000795-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS JAK2, JAK1, BTK AXL 889/4885MERTK 452/4885TYRO3 280/4885
US-20100298334-A1 N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS JAK1, JAK3, JAK2 AXL 449/4885MERTK 794/4885TYRO3 25/4885
US-20190111058-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES JAK1, JAK2, JAK3 AXL 1052/4885MERTK 447/4885TYRO3 284/4885
US-20220378791-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES JAK1, JAK2, JAK3 AXL 1052/4885MERTK 447/4885TYRO3 284/4885
US-20150065447-A1 SURVIVAL BENEFIT IN PATIENTS WITH SOLID TUMORS WITH ELEVATED C-REACTIVE PROTEIN LEVELS JAK2, STAT3, IL6 AXL 589/4885MERTK 172/4885TYRO3 326/4885
US-20150246046-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES JAK1, JAK2, JAK3 AXL 1052/4885MERTK 447/4885TYRO3 284/4885
US-20150342952-A1 TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 JAK1, JAK2, MCL1 AXL 1833/4885MERTK 293/4885TYRO3 947/4885
US-20240091234-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS JAK2, JAK1, BTK AXL 889/4885MERTK 452/4885TYRO3 280/4885
US-20220226327-A1 COMBINATION THERAPY COMPRISING JAK PATHWAY INHIBITOR AND ROCK INHIBITOR JAK1, ROCK1, JAK3 AXL 1369/4885MERTK 1237/4885TYRO3 574/4885
US-11324749-B2 Combination therapy for treatment of hematological diseases JAK1, JAK3, JAK2 AXL 1288/4885MERTK 738/4885TYRO3 999/4885
US-20240058343-A1 TREATMENT OF URTICARIA USING JAK INHIBITORS JAK1, JAK3, JAK2 AXL 559/4885MERTK 507/4885TYRO3 116/4885
US-20140221379-A1 N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS JAK1, JAK3, JAK2 AXL 449/4885MERTK 794/4885TYRO3 25/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.