Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457182 | 0.83 | HTR1A (0.37) | SLC6A4HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL2465088 | 0.82 | SYK (0.36) | HTR1AADRA2AADRA2BADRA2CKDM1A | |
| SCHEMBL14698505 | 0.81 | GBA1 (0.46) | GBA1SLC6A4HTR1AADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL28820807 | 0.78 | SLC6A4 (0.47) | GBA1SLC6A4JAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL18280150 | 0.77 | JAK2 (0.49) | GBA1SLC6A4SLC6A2JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL16825185 | 0.77 | KDM4E (0.44) | GBA1SLC6A4HTR1ASLC6A2JAK2 | |
| SCHEMBL3965587 | 0.76 | GBA1 (0.56) | GBA1SLC6A4HTR1ASLC6A2KDM1A | |
| Hydrochloric Acid SCHEMBL16825163 | 0.76 | SLC6A4 (0.47) | GBA1SLC6A4HTR1ASLC6A2JAK2 | |
| Hydrochloric Acid SCHEMBL18280161 | 0.76 | SLC6A4 (0.44) | GBA1SLC6A4HTR1ASLC6A2JAK2 | |
| SCHEMBL2465174 | 0.75 | HTR1A (0.35) | HTR1AADRA2AADRA2BADRA2CKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719166-A | TREATING PSYCHOSES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-02-17 | — | — | US | disclosed |
| EP-0532177-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5550136-A | ANTAGONISTS OF DOPAMINE D-2 RECEPTORS | ZENECA LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| US-5399568-A | Dopamine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0532177-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |