Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910532 | 0.82 | POLB (0.62) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL13954030 | 0.79 | POLB (0.54) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL4495765 | 0.78 | HTT (0.43) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL4495767 | 0.78 | HTT (0.43) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL14407309 | 0.77 | HTT (0.59) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL4492895 | 0.76 | HTT (0.44) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL10941837 | 0.76 | KDM4E (0.49) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL10624847 | 0.76 | KDM4E (0.52) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL9596191 | 0.74 | HTT (0.47) | HTTPOLBKDM4EHSD17B10GAA | |
| SCHEMBL8600805 | 0.73 | HTT (0.44) | HTTPOLBKDM4EHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345593-B2 | 2-substituted coumaran derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-02-04 | — | — | EP | disclosed |
| EP-0345592-B1 | NOVEL 2-SUBSTITUTED COUMARAN DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-4978761-A | Enzyme inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-12-18 | — | — | US | disclosed |
| US-4966973-A | LIPOXYGENASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-10-30 | — | — | US | disclosed |
| EP-0345593-A1 | 2-substituted coumaran derivatives | Takeda Chemical Industries, Ltd. (JP) | 1989-12-13 | — | — | EP | disclosed |
| EP-0345592-A1 | Novel 2-substituted coumaran derivatives | Takeda Chemical Industries, Ltd. (JP) | 1989-12-13 | — | — | EP | disclosed |