Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | DTYMK | P23919 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18228507 | 0.86 | GPR119 (0.53) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL16825245 | 0.84 | GPR119 (0.51) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL6984087 | 0.84 | GPR119 (0.51) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL18280076 | 0.84 | GPR119 (0.48) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL16825244 | 0.83 | GPR119 (0.60) | GPR119KDM4EPKMMAPTSMN1; SMN2 | |
| SCHEMBL18280179 | 0.83 | GPR119 (0.47) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL18280093 | 0.82 | GPR119 (0.47) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL18280071 | 0.81 | GPR119 (0.47) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL21608352 | 0.81 | ALOX5AP (0.47) | GPR119KDM4EPKMPOLBFAAH | |
| SCHEMBL20835999 | 0.80 | GPR119 (0.56) | GPR119KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719166-A | TREATING PSYCHOSES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-02-17 | — | — | US | disclosed |
| EP-0532177-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5550136-A | ANTAGONISTS OF DOPAMINE D-2 RECEPTORS | ZENECA LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| US-5399568-A | Dopamine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0532177-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |