SCHEMBL8601296

SCHEMBL8601296

O=C(CSc1cc(N=C=S)c(F)cc1Cl)OC1CC1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.33
ALDH1A1 P00352 4/20 0.32
MAPT P10636 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
KDM4E B2RXH2 1/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
GAA P10253 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8602421 0.96 ALDH1A1 (0.37) TDP1ALDH1A1MAPTL3MBTL1KDM4E
SCHEMBL8604172 0.84 ALDH1A1 (0.39) ALDH1A1MAPTL3MBTL1KDM4EPOLB
SCHEMBL8485382 0.84 ALDH1A1 (0.41) TDP1ALDH1A1MAPTKDM4EPOLB
SCHEMBL8603097 0.83
SCHEMBL9770998 0.83 ALDH1A1 (0.37) TDP1ALDH1A1MAPTL3MBTL1KDM4E
SCHEMBL8613689 0.82
SCHEMBL8602482 0.81 ALDH1A1 (0.38) ALDH1A1MAPTL3MBTL1KDM4EHPGD
SCHEMBL8603446 0.81 ALDH1A1 (0.34) ALDH1A1MAPTKDM4ECYP1A2CYP3A4
SCHEMBL8602847 0.81 HSD17B10 (0.43) TDP1ALDH1A1KDM4EHSD17B10CYP1A2
SCHEMBL8603927 0.80 ALDH1A1 (0.38) TDP1ALDH1A1MAPTL3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626370-B1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL CO (JP) 1998-02-11 EP disclosed
EP-0626370-A1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1994-11-30 EP disclosed