Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.80 |
| ▸ | HTR2A | P28223 | 16/20 | 0.80 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601745 | 1.00 | HTR2C (0.80) | HTR2CHTR2AEZH2 | |
| Fumaric Acid SCHEMBL8875032 | 0.91 | HTR2C (0.67) | HTR2CHTR2AEZH2 | |
| Fumaric Acid SCHEMBL8875027 | 0.91 | HTR2C (0.67) | HTR2CHTR2AEZH2 | |
| SCHEMBL8595714 | 0.89 | HTR2C (1.00) | HTR2CHTR2A | |
| SCHEMBL8599014 | 0.89 | HTR2C (1.00) | HTR2CHTR2A | |
| SCHEMBL8595428 | 0.89 | HTR2C (1.00) | HTR2CHTR2A | |
| SCHEMBL8598846 | 0.88 | HTR2C (0.73) | HTR2CHTR2A | |
| SCHEMBL8598849 | 0.88 | HTR2C (0.73) | HTR2CHTR2A | |
| SCHEMBL8597566 | 0.86 | HTR2C (0.78) | HTR2CHTR2A | |
| SCHEMBL8597562 | 0.86 | HTR2C (0.78) | HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |